ea0063gp200 | Diabetes: Pharmacotherapy | ECE2019
Wolfgang Gorgens Sven
, Jahn-Hofmann Kerstin
, Metz-Weidmann Christiane
, Schwahn Uwe
, Wohlfart Paulus
, Schafer Matthias
, Bielohuby Maximilian
Objective: The exopeptidase dipeptidyl peptidase 4 (Dpp4) selectively cleaves N-terminal dipeptides from several substrates, including cytokines, growth factors, neuropeptides, and the incretin hormones. The systemic inhibition of Dpp4 by the so-called gliptins (oral Dpp4 inhibitors) represents an effective and established treatment option for type 2 diabetes (T2D). In the current study we investigated in healthy as well as in obese and diabetic mice if a liver selective knock...